She made the remarks on Wednesday in Harare at the official launch of the Child Survival strategy for the next five years.
In Zimbabwe at least 100 children die every day with treatable diseases.
According to United Nations at least eight Zimbabwean women die every day while giving birth due to chronic underfunding of the health sector.
The child survival strategy which was launched by the government in collaboration with development partners on Wednesday provides a framework for addressing these challenges.
Grace Mugabe attributed maternal and infant mortality rates to sanctions imposed to Zanu (PF) senior members in 2002 by the west.
The West says the sanctions were imposed because of lawlessness which was existing in the country. Since 2002 Zanu (PF) has been hiding its failures to deliver on sanctions imposed on its members by the west.
Zimbabwe bears a heavy burden of high neonatal and child mortality when compared to other countries in other regions in the world. According to the Multiple indicator Monitoring Survey of 2009 under five mortality and infant mortality rates are at 94 and 67 deaths per 1000 births respectively.
Neonatal conditions are the leading causes of mortality in children in the country, with HIV persisting to be the major challenge to child health.
At least 106 000 children are living with HIV, with 90% of the infections being a result of mother to child transmission.
Health and Child Welfare Permanent secretary Dr Gerald Gwinji said the country had been for a long time not prioritising possible measures of reducing maternal and infant mortality rate.
World Health Organisation country representative Dr Custidia Mandhlate said it was everyone’s responsibility to ensure that no child died of treatable diseases.